Biology · Genetics

X-linked recessive Punnett square.

Choose the mother's and father's genotypes for an X-linked recessive trait and see the outcomes for sons and daughters separately.

XX and XYSons and daughtersCarrier mothersChecked 8 October 2026

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Inputs

XA is the normal allele and Xa the recessive allele on the X chromosome.

Children's outcomes

Choose both parents' genotypes.

How X-linked recessive inheritance works

In humans and many other animals, females have two X chromosomes and males have one X and one Y (OpenStax Biology 2e, 12.2). A father passes his Y to his sons, so he cannot pass an X-linked recessive trait to a son; an affected son inherited the gene from his mother (Wikipedia). A son needs only one recessive X to be affected, a daughter needs two, which is why the trait shows more often in males. OpenStax lists some forms of colour blindness, hemophilia and muscular dystrophy as human X-linked conditions.

Worked example. A carrier mother (XAXa) and an unaffected father (XAY): each son has a 50% chance of being affected, matching Wikipedia's 50% for sons of a carrier mother, no daughter is affected and 50% of daughters are carriers. An affected father (XaY) with a non-carrier mother: no son is affected (0%) and every daughter is a carrier (100%). Wikipedia adds that carriers can sometimes show features because of random X-inactivation, and that some scholars suggest dropping the dominant and recessive labels for X-linked traits; this tool uses the classroom convention.

Frequently asked questions

Can a father pass an X-linked recessive trait to his son?

No. Sons get their father's Y chromosome, so an affected son inherited the recessive X from his mother (Wikipedia, X-linked recessive inheritance).

What are the odds for sons of a carrier mother?

Each son has a 50% chance of being affected if the mother is a carrier and 100% if she is affected (Wikipedia, X-linked recessive inheritance).

Why are X-linked recessive traits more common in males?

Males have one X chromosome, so a single recessive copy is enough. Females need a recessive copy from both parents (Wikipedia, X-linked recessive inheritance).

Can a daughter be affected?

Yes, but only if she inherits the recessive X from both parents, so the father must be affected and the mother a carrier or affected.

Does being a carrier always mean no symptoms?

Not always. Wikipedia notes that expression in female carriers can vary because of X-chromosome inactivation. Ask a clinician or genetic counsellor about a specific condition.

Sources

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Teaching model, not advice

A classroom model of one X-linked recessive gene. It is not medical or genetic-counselling advice; talk to a genetic counsellor about any real condition in a family.

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